Table of Contents[Hide][Show]
- Deficiency Common of a Very Important Omega-6
- What is Gamma Linolenic Acid (GLA)?
- Conditions Under Which GLA Deficiency Occurs
- Common Conditions from Gamma Linolenic Acid Deficiency
- Preformed Gamma Linolenic Acid Sources
- Which GLA Source is Best?
- How Much GLA to Take?
- Gamma Linolenic Acid Increases Metabolism
- Harness the Power of Brown Fat
Most people today, health buffs or not, are deficient in gamma linolenic acid, a critical omega-6 fat that is frequently overlooked particularly by those seeking to lose weight and reduce inflammation.
While other healthy lipids such as weight loss boosting coconut oil and muscle-building conjugated linoleic acid (CLA) get all the headlines and attention, gamma linolenic acid (GLA) gets little to no kudos and yet is just as vitally important!
Deficiency Common of a Very Important Omega-6
Even more ironic is that a hallmark of the Western Diet is excessive consumption of omega-6 polyunsaturated fats usually in the form of processed foods cooked or fried in cheap, rancid and frequently genetically modified (GMO) vegetable oils. Even when the sources of these omega-6 fats are whole foods, however, moderate to severe deficiencies of gamma linolenic acid persists even among the seemingly healthy.
The imbalanced intake of fats in the modern diet contributes greatly to the development of a wide variety of inflammatory conditions, weight gain, and overall ill health. Most of the chronic diseases of today, including cancer, diabetes, heart disease, arthritis, Alzheimer’s disease, etc. have an inflammatory component.
While intake of anti-inflammatory omega-3 fats (think salmon, flax seeds, and cod liver oil) to counterbalance the ratio of omega-6 consumption definitely help resolve the problem, it doesn’t solve it entirely.
This is because the frequently overlooked anti-inflammatory properties of gamma linolenic acid have a very important role to play in human health beyond what omega-3 fats have to offer.
What’s more, a nutrient-rich diet that carefully maintains an ideal 1:1 ratio of omega-3 fats to omega-6 fats like ancestral cultures won’t remedy this situation on its own.
What is Gamma Linolenic Acid (GLA)?
In a normal metabolic situation, gamma linolenic acid is produced by the body from the omega-6 fat linoleic acid. The enzyme delta-6-desaturase (D6D) is responsible for the conversion.
The problem is that most people today are experiencing far from a normal metabolic situation!
As mentioned earlier, linoleic acid (LA) or omega-6 polyunsaturated fats are consumed to excess in most people’s diets. Despite this, a deficiency of GLA can easily occur if the D6D enzyme conversion is inefficient of nonexistent.
As it turns out, this happens quite frequently as discussed below.
Conditions Under Which GLA Deficiency Occurs
A number of factors can easily inhibit the body’s conversion of linoleic acid (LA) to gamma linolenic acid even when plenty of LA is present in the diet. These conditions include:
- Overconsumption of sugar and refined grains
- Insulin resistance or diabetes
- Thyroid problems
- Pituitary problems
- Tendency to overeat or being overweight
- Consumption of trans fatty acids
- Overconsumption of alcohol
- Deficiencies of protein, zinc, biotin, B6, B12 and vitamin E
- Being vegan
- Age (the older we get, the less we make this conversion easily)
As if this list wasn’t enough to include nearly everyone today, there are those who are genetically unable to make the conversion. These individuals are called “obligate carnivores” by researchers. Usually, these individuals have ancestors who consumed lots of preformed D6D metabolites in the form of organ meats and fish.
Societies following a carnivore diet such as the Eskimos or Maasai would be populations particularly prone to GLA deficiency due to hereditary factors.
Common Conditions from Gamma Linolenic Acid Deficiency
Gamma linolenic acid deficiency is far more common than believed today. Unfortunately, it is one of the last things practitioners consider or test for when any of the problems below manifest:
- Premature aging
- Cirrhosis of the liver
- Keratosis Pilaris (small, colorless bumps on upper arms or legs)
- PMS and other monthly problems like heavy menstrual bleeding
- Noncancerous breast disease
- Sjogren’s syndrome
- Rheumatoid arthritis
- Inflammatory conditions of all kinds
I can attest to the wonders of resolving a gamma linolenic deficiency when nothing makes sense or seems to work. All three of my children, for example, had keratosis pilaris as toddlers. Nothing helped the situation much except supplementation with gamma linolenic acid (we used borage oil capsules). Now that they are older, they no longer require it, which leads me to think that it may take some time for children to produce the D6D enzyme on their own. While I have not come across any research to this effect, certainly in my own family, early supplementation with GLA proved beneficial until early adolescence was reached.
Preformed Gamma Linolenic Acid Sources
If you suspect that lack of gamma linolenic acid may be the cause of your health issues too, there are two solutions.
First, consume more organ meats such as liver, as these traditional foods contain preformed D6D to fill the gap where your body isn’t creating this enzyme itself for whatever reason. Organ meats also contain small amounts of GLA. Consumption of D6D metabolites allows your body to synthesize the GLA that you need from the likely plentiful omega-6 fats in your diet.
The second alternative is to consume gamma linolenic acid directly. Unfortunately, there are not many foods that contain preformed GLA. These seed oils contain the most as a percentage:
- Borage Oil – 20-24% GLA
- Black Currant Oil – 17% GLA
- Evening Primrose Oil – 10% GLA
- Hemp Seed Oil – 3% GLA
Which GLA Source is Best?
So which of these seed oils is best? Let’s find out by process of elimination.
I would not recommend hemp seed oil for two reasons. It is comparatively low in GLA, and there is no evidence historically that humans ever consumed this oil or valued it for health reasons. That right there is a strike-out for me.
I also would not recommend evening primrose oil as it is an estrogenic food that can cause breakthrough bleeding not associated with menstruation and contribute to precancerous breasts.
This leaves borage oil and black currant oil. We have used both in our home over the years and they have produced equally excellent results. On the positive side, borage oil contains more GLA per dose than black currant oil, so you need to take less of it to achieve a therapeutic dose. However, borage oil does cause gastrointestinal upset in some folks, so if you experience this, switch to black currant oil. These capsules are a quality source.
As with any whole food, take with or after a meal to minimize any digestive discomfort.
How Much GLA to Take?
The good news is that you don’t have to take much gamma linolenic acid to achieve fantastic results. In the case of my children and keratosis pilaris, half to a full 1000 mg borage oil capsule (containing 220 mg GLA) each day was plenty. Since they were young and didn’t easily swallow pills yet, I would just slice open a capsule of borage oil with a knife and squeeze the oil onto a spoon. The oil has a mild taste, so it was well tolerated and easy to swallow.
For older children and adults, the recommended dose of GLA ranges from 300 up to 2,000 milligrams per day for severe deficiency states. In most cases, taking a couple of capsules for a total of about 300 mg GLA per day is sufficient. A split dosage with half in the morning and half in the evening produces the best results. Dr. Weil MD suggests a split dose of 500 mg morning and evening (this would be about 2 capsules morning and another 2 in the evening). He says to expect 6-8 weeks to see results particularly if you are taking GLA to resolve hair, skin, or nail problems (1).
According to the Penn State University Hershey Medical Center, speak with your practitioner to be sure of your individual dosage, and do not exceed 3000 mg/day (2).
Gamma Linolenic Acid Increases Metabolism
While coconut oil and CLA tend to get all the attention as the healthy fats that help weight loss and boost muscle mass, the truth is that gamma linolenic acid is a player too!
GLA works to trigger fat flushing by boosting the metabolism in a very unique way. The process involves stimulation of “brown fat” which increases energy expenditure. This is the type of fat that is usually dormant in overweight people.
Brown fat is also more prevalent in young people and women (this is our secret weapon ladies!). Women with a lower body-mass index tend to have higher levels of metabolically active brown fat.
Human fat consists of white and brown adipose tissue. Most fat is energy-storing white fat, however, even small amounts of brown fat can help induce weight loss through an increase in energy expenditure. The darker color that characterizes brown fat is due to the greater number of mitochondria, which if you remember from high school biology, is the “powerhouse” of the cell. While white fat is the kind that you see on your waistline, thighs and other parts of the body, brown fat is hidden from view. It is located by the organs where it provides padding and protection. It is also safeguards areas surrounding the neck and spine.
Harness the Power of Brown Fat
Here’s how you can harness the power of brown fat to help you lose weight faster according to Ann Louise Gittleman, author of Eat Fat, Lose Weight:
Activating brown adipose tissue—which may amount to as much as 30 to 40 percent of total body mass in some people—can make the battle of the bulge considerably easier. The good news is we don’t have to wait for Big Pharma to develop a drug to stimulate this kind of weight loss.
Back in the 1980s, researchers at the University of Montreal found that gamma-linolenic acid (GLA) is a safe, natural way to stimulate brown fat activity and burn calories. Even people who had been unable to lose weight with other methods lost on average a pound a week with brown-fat burning GLA.
Thanks to the pioneering research of the late David Horrobin, we now know that omega-6-rich GLA also fights inflammatory diseases like arthritis, helps relieve PMS, and is terrific for your skin (2).
Are you frustrated by attempts at using healthy fats to heal with mixed results? If so, it is possible that gamma linolenic acid is an important and missing piece of the puzzle. Note that it takes 3-6 weeks of supplementation to notice the full benefits. Add this crucial fatty acid to your diet and see if you discover, like I was shocked to see, that I was actually deficient despite a healthy traditional diet.
I read borage oil could possibly be toxic. What’s your view, Sarah?
Sarah Pope MGA
Not sure what the reasoning or data for that assertion is. We use borage oil and have for years. Only tiny amounts are needed to achieve the nutritional balancing discussed in this article.
Thank you for letting us know about GLA. Today I’ve received 1kg of borage oil from a UK company which specialises in plant oils (Northstar Lipids, for fellow UK readers) which contains 20% GLA. I’ve just taken my first dose of 2ml of oil, using a syringe that I have for other medicines, and which equates to about 2g or 2000mg. If I understand correctly, this means I’ve taken 400mg of GLA this morning and I’ll take another dose tonight. I may go up to 2.5ml so I can get a bit closer to Dr Weil’s recommendation of 500mg of GLA twice a day.
I’m trying this mainly to see if it helps with lichen sclerosus as well as part of my recovery programme for Chronic Fatigue. We’ll see how I get on!
In general, Is Borage Oil safe to use if trying to conceive or if you are expecting?
Sarah Pope MGA
I’ve read some conflicting info about borage oil for pregnant women. Be sure to check with your practitioner before taking anything if you are expecting.
Thank you so much for the article. I have been struggling with really bad kp since my son was born and now since he is 14 months we both have kp! I was thinking it had something to do with breastfeeding and being deficient in something. I have tried b vitamins, omega 3s, cod liver oil, coconut purée, avocados, egg yolks and nothing has worked. Hopefully gla will help both of us!
I’ve read that borage oil can be toxic to the liver via pyrrolizidine alkaloids. Is this true? I want to give this to my children and I also want to take it but I’m breastfeeding.
Sarah Pope MGA
Borage oil is an issue for some people with sensitive stomachs. I would suggest black currant oil instead as your source for GLA if you have concerns about borage oil.
Are headaches common with GLA? I bought 1000mg black currant oil and I believe they are giving me head aches.
I’ve not read that this is a side effect.
SO glad to find this article on GLA. A number of years ago I had several blood panels that showed a deficiency in GLA, among other things, and I wondered what the heck is that? I since read some articles on contaminants in borage oil, so I gave up the whole idea.
However, I have noticed that the more Omega3’s I take, the worse I feel lately. (I also had dry eye, and 2000 Omega 3’s was prescribed). My skin, hair, nails AND MOOD are suffering. I am a Type 1 Diabetic, under good control…but I have the feeling that my dietary needs may be different from ‘normal’ people’s.
Something is off in my physiology, and so I’ll be adding in Black Current Seed Oil. My caps are 1,000 mg, supplying 170 mg GLA. (and ALA, LA, OA and others).
Is there a good ration of Omega 3’s to GLA to shoot for? And is there any evidence of benefit to heart health?
Hi! I bought some black seed current oil for loosing weight. Solaray 600 mg, says 90 mg of GLA. How many do I need to take for it to work for weight loss. Does that mean I need to take 6 a day? Please reply Thank you Phyl
2-3 per day is plenty. It will not take off weight by itself (they aren’t “diet pills” in other words), but will speed weight loss and improve results when combined with other sensible efforts.
I’ve read and re-read a couple of these articles and super excited to get started. Can I take GLA (black currant capsules) Raw Virgin Coconut Oil and CLA at the same time?
Prosper Mutsa Chitiyo
I have been trying so hard for years to lose weight and have a better shape but it seems I lose very little and end gaining again. What could be the cause? Where can I find GLA in Zimbabwe? My weight is too much. My thighs are too big and even my tummy as well as my butt yet I am a short guy. As a result it has made me look older and I face rejection from many women I approach because of that and even many guys do not want to mix and mingle with me. My height is 1.68 meters and my weight fluctuates between 92 and 95 kg. Can you help supply those products to Zimbabwe?